20380-11-4
基本信息
5,25R-胆甾烯-3BETA,26-二醇
25(R)-27-hydroxy Cholesterol
cholest-(25R)-5-ene-3,27-diol
5,25R-Cholesten-3beta,26-diol
(25R)-Cholest-5-en-3β,26β-diol
(25R)-Cholest-5-ene-3β,26-diol
(3β,25R)-Cholest-5-ene-3,26-diol
(25R)-cholest-5-ene-3beta,26-diol
Cholest-5-ene-3,26-diol, (3β,25R)-
26-Hydroxycholesterol (not deuterated)
物理化学性质
常见问题列表
27-羟基胆固醇是一种内源性的氧化胆固醇,有着多重生物学功能,包括选择性雌激素受体调节物(SERM)活性,肝X受体(LXR)激动剂等,由细胞色素P450氧化酶CYP27A1催化胆固醇生成。
Human Endogenous Metabolite
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27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator that displays significant partial agonist activity in a variety of cellular models of estrogen receptor action. It positively regulates both gene transcription and cell proliferation in cellular models of breast cancer. 27-Hydroxycholesterol, through estrogen receptor activation, triggers deleterious effect in prostate cancer cell lines. 27-Hydroxycholesterol significantly increases cell proliferation of LNCaP and PC3 cells and this effect can be attenuated by estrogen receptor inhibitors. 27-Hydroxycholesterol is an oxysterol produced from cholesterol by the monooxygenase CYP27A1, which regulates intracellular cholesterol homeostasis. 27-Hydroxycholesterol also acts as an endogenous selective estrogen receptor modulator capable of increasing breast cancer growth and metastasis. 27-Hydroxycholesterol levels can be modulated by statins or direct inhibition of CYP27A1, thereby attenuating its pro-tumorigenic activities. 27-hydroxylation of cholesterol is an important pathway for LXR activation in response to cholesterol overload.