205187-35-5
中文名称
205187-35-5
英文名称
2614W94
CAS
205187-35-5
分子式
C15H11F3O4S
分子量
344.31
MOL 文件
205187-35-5.mol
更新日期
2023/03/17 20:03:08
205187-35-5 结构式
基本信息
中文别名
化合物2614W94化合物 T10089
英文别名
2614W94Phenoxathiin, 3-(2,2,2-trifluoro-1-methylethoxy)-, 10,10-dioxide
物理化学性质
沸点440.8±45.0 °C(Predicted)
密度1.449±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
形态Solid
颜色Off-white to light yellow
常见问题列表
生物活性
2614W94是具有选择性的，可逆的monoamine oxidase-A抑制剂，IC50值和Ki值分别为5 nM和1.6 nM。靶点
IC50: 5 nM (Monoamine Oxidase)
Ki: 1.6 nM (Monoamine Oxidase)
体外研究
2614W94 shows potent inhibitory activity against MAO-A, but shows no inhibition of MAO-B at 30 nM.
体内研究
2614W94 (5 mg/kg, p.o.) produces selective inhibition of MAO-A in brains and livers of rats. 2614W94 (5 mg/kg, p.o.) also causes an elevation of neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a concomitant decrease in their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) potentiates 5-hydroxytryptophan-induced head twitches in rats in a dose-dependent manner, with an extrapolated ED 50 of 1.1 mg/kg.