2055024-43-4
中文名称
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
英文名称
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester
CAS
2055024-43-4
分子式
C26H48O12S
分子量
584.72
MOL 文件
2055024-43-4.mol
2055024-43-4 结构式
基本信息
中文别名
炔基-四聚乙二醇-砜-四聚乙二醇-叔丁酯炔基-四聚乙二醇-SULFONE-四聚乙二醇-叔丁酯
英文别名
Propargyl-PEG4-Sulfone-PEG4-BocPropargyl-PEG4-Sulfone-PEG4-t-butyl ester
4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid, 1,1-dimethylethyl ester, 16,16-dioxide
应用领域
用途一
Propargyl-PEG4-Sulfone-PEG4-t-butyl ester is a PEG linker containing a propargyl group and t-butyl protected carboxyl group acid. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions. The protected acid can be deprotected by acidic or basic hydrolysis. The hydrophilic PEG spacer increases solubility in aqueous media.