2055024-64-9
中文名称
Azido-PEG4-Val-Cit-PAB-OH
英文名称
Azido-PEG4-Val-Cit-PAB-OH
CAS
2055024-64-9
分子式
C29H48N8O9
分子量
652.75
MOL 文件
2055024-64-9.mol
2055024-64-9 结构式
常见问题列表
生物活性
Azido-PEG4-Val-Cit-PAB-OH 是一种可降解 (cleavable) 的含 4 个单元 PEG 的 ADC linker,可用于合成抗体偶联药物 (ADC)。Azido-PEG4-Val-Cit-PAB-OH 还是一种 PROTAC linker,属于 PEG 类,可用于合成 PROTAC 分子。靶点
PEGs
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Cleavable
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体外研究
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.