2088001-24-3

中文名称 (S)-benzyl (6-acrylamido-1-(4-(7-hydroxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate

英文名称 (S)-benzyl (6-acrylamido-1-(4-(7-hydroxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate

CAS 2088001-24-3

分子式 C31H34N4O8

分子量 590.62

MOL 文件 2088001-24-3.mol

2088001-24-3 结构式

基本信息物理化学性质应用领域常见问题列表

基本信息

中文别名

化合物 T29086

英文别名

151142
VA5 TG2 inhibitor
(S)-benzyl (6-acrylamido-1-(4-(7-hydroxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl)-1-oxohexan-2-yl)carbamate

物理化学性质

沸点955.8±65.0 °C(Predicted)

密度1.331±0.06 g/cm3(Predicted)

酸度系数(pKa)7.68±0.20(Predicted)

应用领域

用途一

VA5 inhibits both transamidase and GTP-binding activities. Transamidase activity is inhibited by direct inhibitor binding at the transamidase site, and GTP binding is blocked because inhibitor interaction at the transamidase site locks the protein in the extended/open conformation to disorganize/inactivate the GTP binding/GTPase site.

常见问题列表

概述

VA5 是 BTK 激酶抑制剂。VA5 有潜力用于研究与 BTK 激酶活性相关的疾病。