2089617-83-2
2089617-83-2 结构式
物理化学性质
沸点562.0±60.0 °C(Predicted)
密度1.137±0.06 g/cm3(Predicted)
储存条件2-8°C
溶解度DMSO: 2mg/mL, clear (warmed)
酸度系数(pKa)8.66±0.10(Predicted)
形态powder
颜色white to beige
应用领域
用途一
MS012 is a Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. MS012 exhibited stronger binding affinity to GLP (Kd = 46 ± 15 nM) than G9a (Kd = 610 ± 68 nM). MS012 was 13-fold selective for GLP over G9a. G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates.