2093946-08-6

中文名称化合物 YQ456

英文名称 Benzamide, 3-[3-ethyl-5-(4-methoxyphenyl)-1H-1,2,4-triazol-1-yl]-N-(4-phenylbutyl)-

CAS 2093946-08-6

分子式 C28H30N4O2

分子量 454.56

MOL 文件 2093946-08-6.mol

2093946-08-6 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 YQ456

英文别名

Benzamide, 3-[3-ethyl-5-(4-methoxyphenyl)-1H-1,2,4-triazol-1-yl]-N-(4-phenylbutyl)-

物理化学性质

密度1.14±0.1 g/cm3(Predicted)

酸度系数(pKa)14.20±0.46(Predicted)

形态Solid

颜色White to off-white

应用领域

用途一

YQ456 is a novel potent and selective inhibitor of myoferlin (MYOF inhibitor), which attenuates colorectal cancer progression. YQ456 showed high binding affinity to MYOF (KD = 37 nM) and excellent anti-invasion capability (IC50 = 110 nM). YQ456 was reported for the first time to interfere with the interactions between MYOF and Ras-associated binding (Rab) proteins at low nanomolar levels. This interference disrupted several vesicle trafficking processes, including lysosomal degradation, exosome secretion, and mitochondrial dynamics. Further, YQ456 exhibited excellent inhibitory effects on the growth and invasiveness of colorectal cancer. As the first attempt, the anticancer efficacy of YQ456 in the patient-derived xenograft (PDX) mouse model indicated that targeting MYOF may serve as a novel and practical therapeutic approach for colorectal cancer.