2102672-22-8
2102672-22-8 结构式
物理化学性质
沸点417.7±45.0 °C(Predicted)
密度1.611±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 83.33 mg/mL (204.39 mM)
酸度系数(pKa)7.22±0.10(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
DK419 is a potent inhibitor of Wnt/β-catenin signaling and colorectal cancer growth. DK419 inhibited Wnt/β-catenin signaling, altered cellular oxygen consumption rate and induced production of pAMPK. DK419 inhibited the growth of CRC tumor cells in vitro, had good plasma exposure when dosed orally, and inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.常见问题列表
概述
DK419 是一种有效、可口服的 Wnt/β-catenin 信号通路抑制剂，IC50 值为 0.19 μM。DK419 能降低 Axin2，β-catenin，c-Myc，Cyclin D1 和 Survivin 能够改变细胞内耗氧率，诱导 pAMPK 的产生。