2128304-54-9
中文名称
化合物 TQ0242L
英文名称
Fenebrutinib (GDC-0853) HCl
CAS
2128304-54-9
分子式
C37H45ClN8O4
分子量
701.27
MOL 文件
2128304-54-9.mol
2128304-54-9 结构式
应用领域
用途一
Fenebrutinib, also known as GDC-0853, is orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, GDC-0853 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.