2132410-88-7

中文名称 5,8-Quinazolinedione, 6-([1,1'-biphenyl]-4-ylamino)-

英文名称 5,8-Quinazolinedione, 6-([1,1'-biphenyl]-4-ylamino)-

CAS 2132410-88-7

分子式 C20H13N3O2

分子量 327.34

MOL 文件 2132410-88-7.mol

2132410-88-7 结构式

基本信息应用领域

基本信息

中文别名

化合物 T24693

英文别名

QD325
QD-325
QD 325
5,8-Quinazolinedione, 6-([1,1'-biphenyl]-4-ylamino)-

应用领域

用途一

QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. QD325 can induce substantial reactive oxygen species (ROS) in PDAC cells. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells. Furthermore, QD325 induced Nrf2-mediated oxidative stress and unfolded protein responses as demonstrated by dose dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3 and HSPA5. QD325 is as a new therapeutic in the treatment of PDAC.