222989-99-3

中文名称 222989-99-3

英文名称 Finasteride (acetate)

CAS 222989-99-3

分子式 C25H40N2O4

分子量 432.596

MOL 文件 222989-99-3.mol

222989-99-3 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

醋酸非那雄胺
醋酸非那斯特萊

英文别名

MK-906 acetate
Finasteride (acetate)

所属类别

生物化工：激动剂抑制剂

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

常见问题列表

生物活性

Finasteride (MK-906) acetate 是一种有效的竞争性 5α-还原酶 (5α-reductase) 抑制剂，对 II 型 5α-还原酶的 IC50 值为 4.2 nM。Finasteride acetate 对 II 型 5α-还原酶的亲和力比对 I 型酶高约 100 倍。Finasteride acetate 可用于研究前列腺增生 (BPH) 和雄激素性脱发。

靶点

IC50: 4.2 nM (type II 5α-reductase)

体外研究

Finasteride (10 μM; 6-24 h) induces the expression of HO-1 and Nrf2 proteins in PC-3 cells.
Finasteride decreases the conversion of [ ³ H]testosterone (T) to [ ³ H]dihydrotestosterone (DHT) in P. crustosum .

Cell Viability Assay

Cell Line:	PC-3, DU-145, and LNCaP cells
Concentration:	10 μM
Incubation Time:	6, 12, 24 h
Result:	Increased the expression of HO-1 protein in a time-dependent manner in PC-3 cells. Induced the expression of Nrf2 protein in DU-145 and PC-3 cells, but not in LNCaP cells.

体内研究

Finasteride (0.1-0.5 mg/kg; p.o. once daily for 16 weeks) reduces prostatic size in dogs with BPH without adversely affecting semen quality or serum testosterone concentration.

Animal Model:	Male dogs with spontaneous BPH (2.7-11 years old; 10.3-49 kg)
Dosage:	0.1-0.5 mg/kg
Administration:	P.o. once daily for 16 weeks
Result:	Decreased prostatic diameter (20%), prostatic volume (43%), and serum DHT concentration (58%). Decreased semen volume but did not adversely effect on semen quality or serum testosterone concentration. No adverse effects on dogs.