2235394-90-6
2235394-90-6 结构式
基本信息
中文别名
6-[(3S,4S)-4-氨基-3-甲基-2-氧杂-8-氮杂螺[4.5]癸烷-8-基]-3-[3-氯-2-(环丙基氨基)-4-吡啶基]-5-甲基-2H-吡唑并[3,4-D]嘧啶-4(5H)-酮 英文别名
SHP389物理化学性质
沸点733.1±70.0 °C(Predicted)
密度1.67±0.1 g/cm3(Predicted)
酸度系数(pKa)6.87±0.20(Predicted)
形态Solid
颜色White to off-white
应用领域
用途一
SHP389 is an allosteric SHP2 Inhibitor with (SHP2 IC50 - 36 nM). SHP389 modulates MAPK signaling in vivo.SHP389 improved SHP2 biochemical and cellular potency in trend with increasing lipophilicity.