2238822-07-4

中文名称化合物 GDC-2394

英文名称 5H-Pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-6,7-dihydro-6-(methylamino)-, (6S)-

CAS 2238822-07-4

分子式 C20H25N5O4S

分子量 431.51

MOL 文件 2238822-07-4.mol

2238822-07-4 结构式

基本信息物理化学性质应用领域

基本信息

中文别名

化合物 GDC-2394

英文别名

5H-Pyrazolo[5,1-b][1,3]oxazine-3-sulfonamide, N-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-6,7-dihydro-6-(methylamino)-, (6S)-

物理化学性质

密度1.63±0.1 g/cm3(Predicted)

酸度系数(pKa)4.47±0.20(Predicted)

形态Solid

颜色White to off-white

应用领域

用途一

GDC-2394 is a A Potent and Selective NLRP3 Inhibitor with an in vitro and in vivo safety profile suitable for advancement into human clinical trials. GDC 2394 Inhibits In Vivo Production of IL-1β in an Acute Mouse Peritonitis Model. GDC 2394 Reduces Paw Swelling and Pain in a Functional Rat Model of Gouty Arthritis.