2332897-85-3
中文名称
Nav1.1 activator 1
英文名称
Nav1.1 activator 1
CAS
2332897-85-3
分子式
C24H23F3N4O
分子量
440.46
MOL 文件
2332897-85-3.mol
2332897-85-3 结构式
物理化学性质
沸点533.1±50.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
储存条件-20°C储存
酸度系数(pKa)11.63±0.70(Predicted)
形态Solid
颜色White to off-white
Nav1.1 activator 1价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-126429 | Nav1.1 activator 1 | 2332897-85-3 | 1 mg | 1409元 |
| 2025/05/22 | HY-126429 | Nav1.1 activator 1 Nav1.1 activator 1 | 2332897-85-3 | 5mg | 3100元 |
| 2025/05/22 | HY-126429 | Nav1.1 activator 1 Nav1.1 activator 1 | 2332897-85-3 | 10mM * 1mLin DMSO | 3410元 |
常见问题列表
生物活性
Nav1.1 activator 1 (compound 4) 是强有效的、能透过血脑屏障的、 Nav1.1 激动剂，0.03 μM 可增加衰减Nav1.1 电流的时间常数 τ。对 Nav1.2、Nav1.5、Nav1.6 有显著的选择性。靶点
Na v 1.1.
体内研究
Nav1.1 activator 1 (compound 4) is a valuable Na v 1.1 activator for further evaluation of pathophysiological functions of the Nav1.1 channel and has potential for therapeutic treatments of CNS diseases such as Dravet syndrome.
| Animal Model: | Mice. |
| Dosage: | 30 mg/kg ( Pharmacokinetic Analysis ). |
| Administration: | IP once (Exposure was measured at 1 h after administration). |
| Result: |
Intraperitoneal administration (30 mg/kg) of compound resulted in sufficient brain exposure (193 ng/g 1 h after administration), which corresponded to 13 nM of free brain concentration comparable to the in vitro potency of the compound.
Had a potential use as an in vivo tool to investigate whether this type of Na v 1.1 activator can restore Na v 1.1 functions and modify the disease state in animal models. Could penetrate the blood-brain barrier (BBB) in humans. |