2368927-41-5
中文名称
化合物 PH-HTBA
英文名称
Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)-
CAS
2368927-41-5
分子式
C19H18O3
分子量
294.34
MOL 文件
2368927-41-5.mol
2368927-41-5 结构式
基本信息
中文别名
化合物 PH-HTBA 英文别名
Acetic acid, 2-(5,7,8,9-tetrahydro-5-hydroxy-2-phenyl-6H-benzocyclohepten-6-ylidene)-, (2E)-应用领域
用途一
Ph-HTBA a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKIIα Hub Domain. Ph-HTBA showed enhanced mid-nanomolar affinity for the CaMKIIα binding site and a marked hub thermalstabilization effect along with a distinct CaMKIIα Trp403 flip upon binding. Moreover, Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice, signified by a high Kp, uu value (0.85). Ph-HTBA is a promising candidate for CaMKIIα-associated pharmacological interventions and future clinical development.