2378114-72-6
中文名称
LANREOTIDE ACETATE
英文名称
Lanreotide acetate
CAS
2378114-72-6
分子式
C56H73N11O12S2
分子量
1156.39
MOL 文件
2378114-72-6.mol
更新日期
2024/07/31 16:57:48
2378114-72-6 结构式
物理化学性质
形态Solid
颜色White to off-white
序列{d-2nal}-Cys-Tyr-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)
LANREOTIDE ACETATE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/16 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 5mg | 892.93元 |
| 2024/01/16 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 25mg | 2678.21元 |
| 2021/06/02 | P1088 | LANREOTIDE ACETATE Lanreotide acetate | 2378114-72-6 | 5mg | 892.93元 |
常见问题列表
生物活性
Lanreotide (Laromustine, Angiopeptin, BIM 23014, Dermopeptin, Ipstyl, ITM-014, Somatulina, Somatuline, Lanreotidum) acetate 是一种天然生长抑素肽的类似物，是生长激素 growth hormone (GH)的生理抑制剂。Lanreotide 也具有抗肿瘤作用。体外研究
Lanreotide acetate (BIM 23014 acetate) (24-48 hours; 100 nM; GH3 cells) combines with radiation increasing in apoptotic sub-G1 proportion.
Lanreotide acetate results in a dose-dependent decrease in GH3 cell colony forming units. Lanreotide acetate at doses of 1, 10, 100, and 1000 nM results in cell survival rates of 75, 56, 39 and 27% respectively. The IC50 (50% inhibition of cell growth) was 57 nM.
Lanreotide acetate inhibits GH-secreting pituitary adenoma cell proliferation and hormone release in vitro.
体内研究
Lanreotide acetate (2.5-10mg/kg; s.c.; daily for 5 days) resluts in tumor growth inhibition.
| Animal Model: | Male nude mice, 8 weeks old and 20–25 g in body weight (GH3 tumor-bearing nude mice) |
| Dosage: | 2.5, 5, 10 mg/kg |
| Administration: | Subcutaneous; daily for 5 days |
| Result: | Produced tumor growth inhibition. |