2553217-91-5
2553217-91-5 结构式
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/05/22 | HY-135659 | BSH-IN-1 | 2553217-91-5 | 1 mg | 1580元 |
| 2025/05/22 | HY-135659 | BSH-IN-1 BSH-IN-1 | 2553217-91-5 | 10mM * 1mLin DMSO | 3551元 |
| 2025/05/22 | HY-135659 | BSH-IN-1 BSH-IN-1 | 2553217-91-5 | 5mg | 3950元 |
常见问题列表
BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta VPI-5482, Bacteroides fragilis ATCC 25285, and Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum WCFS1, C. perfringens ATCC 13124, and Bifidobacterium adolescentis L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC 50 s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively.
BSH-IN-1 (Compound 7; 10 mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted.
| Animal Model: | C57BL/6 mice |
| Dosage: | 10 mg/kg |
| Administration: | Single gavage |
| Result: | Inhibited gut bacterial BSH activity and modulated the bile acid pool in vivo while not significantly affected the gut bacterial community. |