基本信息
中文别名
派利文碱1派利文碱对照品
派利文碱标准品
英文别名
PerivinPoly alkali
4-Demethyl-3-oxovobasan-17-oic acid methyl ester
Vobasan-17-oic acid,4-demethyl-3-oxo-, methyl ester
Vobassan-17-oic acid, 4-demethyl-3-oxo-, methyl ester
5-Ethylidene-2,3,4,5,6,7,8,9-octahydro-8-oxo-2,6-methano-1H-azecino[5,4-b]indole-14-carboxylic acid methyl ester
常见问题列表
生物活性
Perivine (Perivin) 以视网膜母细胞瘤相关蛋白 (RbAp48) 为靶点，用于解决 RbAp48-FOG-1 复合物的不稳定性。Perivine 可用于阿尔茨海默病的研究。靶点
IC50: Retinoblastoma-associated proteins (RbAp48)
体外研究
Retinoblastoma-associated proteins (RbAp48) are related to Alzheimer's disease (AD), RbAp48 forms a complex with the peptide FOG-1 (friend of GATA-1) and has a role in gene transcription. However, this is an unstable complex may affect the function of RbAp48. Perivine has a greater stable affinity for RbAp48 binding than FOG1, it might resolve the instability of the RbAp48-FOG1 complex and thus be used in AD therapy.