2738-64-9

中文名称粉蝶霉素A

英文名称 PIERICIDIN A

CAS 2738-64-9

分子式 C25H37NO4

分子量 415.57

MOL 文件 2738-64-9.mol

更新日期 2024/04/16 13:56:28

2738-64-9 结构式

基本信息物理化学性质安全数据粉蝶霉素A价格(试剂级) 常见问题列表

基本信息

中文别名

抗生素
粉蝶霉素A
杀粉蝶菌素A

英文别名

SN 198E
IT-143D
piericidin
piericidinea
PIERICIDIN A
PIERICIDIN A1
SHAOGUAMYCIN B
SHAOGUANMYCIN B
piericidin(sub1)
piericidin a from microbial source

物理化学性质

沸点614.9±55.0 °C(Predicted)

密度1.044±0.06 g/cm3(Predicted)

闪点85 °C

储存条件2-8°C

溶解度可溶于DMSO（高达25mg/ml）或乙醇（高达20mg/ml）。

酸度系数(pKa)5.21±0.33(Predicted)

形态liquid

颜色green-yellow

稳定性Stable for 2 years from date of purchase as supplied. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H315-H319-H335

防范说明P261-P271-P280

危险品标志T+,Xn

危险类别码26/27/28-20/21/22

安全说明28-36/37-45

危险品运输编号UN 3382 6.1/PG 1

WGK Germany3

RTECS号YD4588000

F3-10

海关编码2933399990

粉蝶霉素A价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/01/25	HY-114936	粉蝶霉素A Piericidin A	2738-64-9	1mg(12.03mM * 200μL in Ethanol)	4500元

常见问题列表

生物活性

Piericidin A (AR-054) 是一种天然线粒体 NADH-泛醌氧化还原酶 (复合物 I; complex I) 抑制剂。Piericidin A 是一种有效的神经毒素，通过其对 NADH-泛醌还原酶 (NADH-ubiquinone reductase) 的作用破坏电子传输系统，从而抑制线粒体呼吸。Piericidin A 还是一种潜在的群体感应抑制剂，可抑制胡萝卜欧文氏菌亚种 atroseptica (Eca) 的毒力基因的表达。Piericidin A 是一种 ADC 细胞毒素，具有抗菌，抗癌，杀虫活性。

体外研究

In a cell free assay, the potency of Piericidin A to inhibit mitochondrial complex I is ∼2 fold smaller than the one of annonacin. In cultured neurons, Piericidin A potently induces the redistribution of phosphorylated tau from the dendrites into the cell soma and induces cell death.
The viability of Tn5B1-4 cells is inhibited by Piericidin A in a time- and concentration-dependent manner with IC ₅₀ value of 0.061 μM, whilst Piericidin A shows slight inhibitory effect on the viability of HepG2 and Hek293 cells with IC ₅₀ value of 233.97 μM and 228.96 μM, respectively. Piericidin A induces apoptosis of Tn5B1-4 cells coincides with a decrease in the mitochondrial membrane potential.

体内研究

Piericidin A (0.5 mg/kg/d; for 28 days via osmotic minipumps) significantly increases the number of phospho-tau immunoreactive cells in the cerebral cortex in P301S ^+/+ mice. Piericidin A leads to increased levels of pathologically phosphorylated tau only in P301S ^+/+ mice. The synaptic density is reduced by Piericidin A treatment in P301S ^+/+ mice. Exposure to Piericidin A aggravates the course of genetically determined tau pathology.