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285986-31-4

中文名称 STAT5 Inhibitor
英文名称 STAT5 Inhibitor
CAS 285986-31-4
分子式 C16H11N3O3
分子量 293.28
MOL 文件 285986-31-4.mol
更新日期 2024/05/27 10:33:45
285986-31-4 结构式 285986-31-4 结构式

基本信息

中文别名
STAT5抑制剂
化合物STAT5 INHIBITOR
STAT5抑制剂(STAT5-IN-1)
英文别名
CS-2509
MDK6314
STAT5-IN-1
STAT5 Inhibitor
STAT5 Inhibitor 1
N'-[(4-oxo-4H-chromen-3-yl)methylene]nicotinohydrazide
(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
3-Pyridinecarboxylic acid, 2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazide
所属类别
生物化工:抑制剂

物理化学性质

熔点214-216 °C
密度1.33±0.1 g/cm3(Predicted)
储存条件Keep in dark place,Sealed in dry,2-8°C
溶解度≥9.58 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
酸度系数(pKa)10.44±0.46(Predicted)
形态结晶固体
STAT5 Inhibitor价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-101853STAT5 Inhibitor
STAT5-IN-1
285986-31-45mg550元
2024/04/30S6784STAT5 Inhibitor
STAT5-IN-1
285986-31-45mg557.25元
2024/04/30HY-101853STAT5 Inhibitor
STAT5-IN-1
285986-31-410mM * 1mLin DMSO605元

常见问题列表

生物活性
STAT5-IN-1 是一种有效的选择性 STAT5 抑制剂,其对于STAT5β亚型的IC50值为47 μM。
靶点
TargetValue
STAT5β
(Cell-free assay)
47 μM
体外研究

The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members.

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