29734-68-7
中文名称
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
英文名称
(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
CAS
29734-68-7
分子式
C16H21NO3.BrH
分子量
356.25
MOL 文件
29734-68-7.mol
29734-68-7 结构式
基本信息
中文别名
化合物 T11041(2S,13BS)-2-METHOXY-2,3,5,6,8,9,10,13-OCTAHYDRO-1H,12H-BENZO[I]PYRANO[3,4-G]INDOLIZIN-12-ONE HYDROBROMIDE
英文别名
DHβE hydrobromide-erythroidineHydrobromide
-erythroidine hydrobromide
Dihydro-2-erythroidine Hydrobromide
DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE
Dihydro-β-erythroidine hydrobromide
Dihydro-β-erythroidine hydrobromide
DIHYDRO-BETA-ERYTHROIDINE HYDROBROMIDE
DIHYDRO-B-ERYTHROIDINE HYDROBROMIDE COMP ETITIVE NICOTINIC
3β-1,6-Didehydro-14,17-dihydro-3-methoxy-16(15H)-oxaerythrinan-15-one hydrobromide
常见问题列表
生物活性
Dihydro-β-erythroidine (DHβE) hydrobromide 是一种有效竞争性的,具有口服活性的神经 nAChRs 拮抗剂。Dihydro-β-erythroidine hydrobromide 对 α4β4 和 α4β2 有选择性,IC50 分别为 0.19 和 0.37 μM。具有抗抑郁类活性。体内研究
Dihydro-Beta-Erythroidine hydrobromide (DHβE hydrobromide; 10 nmol/0.5 μL) is infused into the respective areas prior to a systemic nicotine injection (0.2 mg/kg; SC). DHβE infused into the ventral tegmental area (VTA), nucleus accumbens (NAcc), or infralimbic (IL) cortex, but not prelimbic (PrL) cortex, attenuated nicotine-enhanced responding for a conditioned reinforcer (CRf).
The co-administration of Dihydro-Beta-Erythroidine hydrobromide (5.0 mg/kg; s.c) with nicotine (0.2 and 0.4 mg/kg; s.c.) prevents the development of conditioned taste aversions (CTAs).
Animal Model: | Male hooded Lister rats |
Dosage: | 0.5, 1.6 and 5.0 mg/kg |
Administration: | S.c. |
Result: | A complete blockade of the nicotine effect produced by the training dose of nicotine (0.2 mg/kg). |