312608-54-1
中文名称
4-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
英文名称
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)
CAS
312608-54-1
分子式
C12H11N3O4S
分子量
293.3
MOL 文件
312608-54-1.mol
更新日期
2025/05/13 19:27:07
312608-54-1 结构式
基本信息
中文别名
化合物MID-14-乙氧基-N-(5-硝基噻唑-2-基)苯甲酰胺
英文别名
ChemBridge56558964-ethoxy-N-(5-nitrothiazol-2-yl)benzamide
Benzamide, 4-ethoxy-N-(5-nitro-2-thiazolyl)
物理化学性质
密度1.442±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: 31.25 mg/mL (106.55 mM)
酸度系数(pKa)6.62±0.50(Predicted)
形态Solid
颜色Orange to red
常见问题列表
生物活性
MID-1 是一种 MG53-IRS-1 (Mitsugumin 53-胰岛素受体底物 1) 相互作用的抑制剂。 MID-1 破坏了 MG53 与 IRS-1 的分子缔合，并消除了 MG53 诱导的 IRS-1 泛素化和骨骼肌降解，从而导致 IRS-1 表达水平升高，胰岛素信号传导和葡萄糖摄取增加。体外研究
MID-1 (5 μM; 24 h) increases the IRS-1 expression level in skeletal muscle by disrupting the MG53-IRS-1 interaction.
MID-1 (10 μM; 12 h) reduces the luciferase activity in HEK 293 cell line expressing NLUC-IRS-1 and CLUC-C14A.
MID-1 (1-20 μM; 12 h) disrupts the MG53-IRS-1 interaction but not MG53-FAK interaction in HEK 293 cells.
MID-1 (0.1-10 μM; 4-24 h) abolishes MG53-induced IRS-1 ubiquitination and degradation in HEK 293 cells.
MID-1 (5-10 μM; 24 h) increases insulin signaling and insulin-elicited glucose uptake in C2C12 myotubes.
MID-1 (5-10 μM; 24 h) enhances skeletal myogenesis.
Western Blot Analysis
| Cell Line: | C2C12 myotubes |
| Concentration: | 5 μM |
| Incubation Time: | 24 h |
| Result: | Increased the IRS-1 protein level. |
体内研究
MID-1 does not have good pharmacokinetics in vivo.