32385-58-3
中文名称
S-[2-(4(5)-咪唑基)乙基]异硫脲氢溴酸盐
英文名称
IMETIT DIHYDROBROMIDE
CAS
32385-58-3
分子式
C6H12Br2N4S
分子量
332.06
MOL 文件
32385-58-3.mol
更新日期
2026/03/11 15:07:34
32385-58-3 结构式
基本信息
中文别名
IMETIT 氢溴酸盐S-[2-(4(5)-咪唑基)乙基]异硫脲氢溴酸盐
英文别名
IMETIT DIHYDROBROMIDEVUF 8325 dihydrobromide
SKF 91105 dihydrobromide
S-[2-(Imidazol-4-yl)ethyl]isothiourea2HBr
IMETIT DIHYDROBROMIDE POTENT AND SELECTI VE
5-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
S-[2-(IMIDAZOL-4-YL)ETHYL]ISOTHIOUREA DIHYDROBROMIDE
S-[2-(4(5)-Imidazolyl)ethyl]isothiourea dihydrobromide
CarbaMiMidothioic acid, 2-(1H-iMidazol-4-yl)ethyl ester, dihydrobroMide
物理化学性质
储存条件Store at RT
溶解度H2O: soluble
溶解度可溶于水中
形态solid
颜色off-white
水溶解性Freely soluble in water, practically insoluble in acetone
/n
InChI1S/C6H10N4S.2BrH/c7-6(8)11-2-1-5-3-9-4-10-5;;/h3-4H,1-2H2,(H3,7,8)(H,9,10);2*1H
InChIKeyDOBOYMKCRRLTRF-UHFFFAOYSA-N
SMILESBr[H].Br[H].NC(=N)SCCc1c[nH]cn1
安全数据
警示词警告
危险性描述H315-H319-H335
危险品标志Xi
危险类别码36/37/38
安全说明26-36
WGK Germany3
WGK Germany3
存储类别11 - Combustible Solids
危险性类别Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Skin Irrit. 2
STOT SE 3
常见问题列表
生物活性
Imetit dihydrobromide (VUF 8325 dihydrobromide) 是组胺 H3 和 H4 受体的高亲和力的强激动剂，Ki 值分别为 0.3 和 2.7 nM。Imetit dihydrobromide 模拟组胺对嗜酸性粒细胞形状改变的作用 (EC50=25 nM)。靶点
|
H 3 Receptor 0.3 nM (Ki) |
H 4 receptor 2.7 nM (Ki) |
体内研究
Imetit dihydrobromide (2.5-10 mg/kg; i.p.) reduces the licking response induced by Apomorphine.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 2.5, 5, 10 mg/kg |
| Administration: | i.p. (30 min before Apomorphine) |
| Result: | Reduced the licking response induced by Apomorphine. |