32694-37-4
![32694-37-4 结构式](/CAS/20180808/GIF/32694-37-4.gif)
基本信息
17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
11-Ketodihydrotestosterone
5α-dihydro-11-keto Testosterone
17β-Hydroxy-5α-androstane-3,11-dione
5.alpha.-dihydro-11-keto Testosterone
5alpha-Androstane-3,11-dione-17beta-ol
17beta-Hydroxy-5alpha-androstane-3,11-dione
Androstane-3,11-dione, 17-hydroxy-, (5α,17β)-
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/04/30 | HY-135794 | 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮 11-Ketodihydrotestosterone | 32694-37-4 | 5mg | 3500元 |
2024/04/30 | HY-135794 | 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮 11-Ketodihydrotestosterone | 32694-37-4 | 10mM * 1mLin DMSO | 3850元 |
2024/04/30 | HY-135794 | 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮 11-Ketodihydrotestosterone | 32694-37-4 | 10mg | 6300元 |
常见问题列表
Ki: 20.4 nM (Human androgen receptor)
EC50: 1.35 nM (Human androgen receptor)
11-Ketodihydrotestosterone (11-KDHT; 1-10 nM; 24 hours; LNCaP and VCaP cells) treatment induces significant cell proliferation.
11-Ketodihydrotestosterone (11-KDHT; 0.1-10 nM; 7-10 days; LNCaP and VCaP cells) treatment results in the significant upregulation of
KLK3
,
TMPRSS2
and
FKBP5
in both LNCaP and VCaP cells, with the exception of
KLK3
at 1 nM in LNCaP cells.
In PNT2 cells, only 20% of 11β-hydroxyandrostenedione (11OHA4) and 11β-hydroxytestosterone (11OHT) are metabolised with the former yielding 11keto-androstenedione (11KA4), 11-Ketodihydrotestosterone (11-KDHT) and 11β-hydroxy-5α-androstanedione (11OH-5αDIONE) and the latter yielding 11OHA4, 11KT and 11-Ketodihydrotestosterone with downstream products <0.03 μM.
In prostate cancer tissue, C11-oxy C19 metabolites at significantly higher levels than the C19 steroids are detected, with unconjugated 11-Ketodihydrotestosterone, 11KT and 11OHA4 levels ranging between 13 and 37.5 ng/g. Analyses of total steroid levels in plasma show significant levels of 11OHA4 (≈230-440 nM), 11KT (≈250-390 nM) and 11-Ketodihydrotestosterone (≈19 nM).
Cell Proliferation Assay
Cell Line: | LNCaP and VCaP cells |
Concentration: | 0.1 nM, 1 nM or 10 nM |
Incubation Time: | 7 days (LNCaP cells) or 10 days (VCaP cells) |
Result: | Induced significant cell proliferation. |
RT-PCR
Cell Line: | LNCaP and VCaP cells |
Concentration: | 1 nM, 10 nM |
Incubation Time: | 24 hours |
Result: | Resulted in the significant upregulation of KLK3 , TMPRSS2 and FKBP5 in both LNCaP (Fig 3) and VCaP (Fig 4) cells. |