34334-69-5
中文名称
条叶蓟素
英文名称
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
CAS
34334-69-5
分子式
C17H14O7
分子量
330.29
MOL 文件
34334-69-5.mol
更新日期
2023/03/20 15:41:25
34334-69-5 结构式
基本信息
中文别名
中国蓟醇条叶蓟素
英文别名
CIRSILIOLCrisiliol
Cirsiliol >=95% (HPLC)
3'-Hydroxy-6-methoxygenkwanin
3',4',5-Trihydroxy-6,7-dimethoxy
6-Methoxyluteolin 7-methyl ether
6-Hydroxyluteolin-6,7-dimethyl ether
6,7-DIMETHOXY-5,3',4'-TRIHYDROXYFLAVONE
6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
6,7-DIMETHOXY-3,4'',5-TRIHYDROXYFLAVONE 95+%
所属类别
天然产物：黄酮类化合物物理化学性质
熔点280-281.5℃ (methanol )
储存条件2-8°C
溶解度Acetone: soluble; Chloroform: soluble; DMSO: soluble
形态粉末
颜色白色至米色
常见问题列表
生物活性
Cirsiliol是有效和选择性的5-脂氧合酶 (5-lipoxygenase) 抑制剂，并且是竞争性低亲和力的苯二氮卓受体配体。靶点
|
5-Lipoxygenase
|
体外研究
In concentrations from 0.01 to 300 μM, cirsiliol causes concentration-dependent relaxation of rat isolated ileum. Cirsiliol may inhibit Ca 2+ influx but stimulates Ca 2+ release from intracellular stores. Treatment with rhamnetin or cirsiliol reduces the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression.
体内研究
In xenograft mouse model, tumor volume is significantly reduced by combinational treatment with irradiation and rhamnetin or cirsiliol compared with irradiation alone.