34433-31-3
中文名称
ASOXIME CHLORIDE
英文名称
ASOXIME CHLORIDE
CAS
34433-31-3
分子式
C14H16Cl2N4O3
分子量
359.21
MOL 文件
34433-31-3.mol
34433-31-3 结构式
基本信息
英文别名
hi6hj6
hi-6
wr249655
Transant
Ccris 7699
HI 6 Chloride
hi-6dichloride
ASOXIME CHLORIDE
pyridinium,4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-,dichloride,2-oxi
常见问题列表
生物活性
Asoxime dichloride 是乙酰胆碱受体 (AChRs) 拮抗剂，包括烟碱受体，α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用，改善神经系统的免疫效果。靶点
IC50: acetylcholine receptors (AChRs)
体内研究
Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant.
| Animal Model: | Balb/c mice |
| Dosage: | 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg |
| Administration: | Intramuscular injection into the rear limb |
| Result: | Improved vaccination efficacy at the level of immunity regulation by the nervous system. |