355129-15-6
中文名称
伊罗替罗
CAS
355129-15-6
分子式
C18H17Br2NO5
分子量
487.14
MOL 文件
355129-15-6.mol
更新日期
2023/03/20 15:41:19
355129-15-6 结构式
基本信息
中文别名
伊罗替罗N-[3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基]丙酰胺酸
3-((3,5-二溴-4-(4-羟基-3-异丙基苯氧基)苯基)氨基)-3-氧丙酸
英文别名
Kb-2115eprotirome
Unii-958aq7B6R1
KB2115 Exclusive
VPCSYAVXDAUHLT-UHFFFAOYSA-N
N-[3,5-Dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenyl]malonamic acid
3-((3,5-Dibromo-4-(4-hydroxy-3-(1-methylethyl)phenoxy)phenyl)amino)-3-oxopropanoic acid
Propanoic acid,3-[[3,5-dibroMo-4-[4-hydroxy-3-(1-Methylethyl)phenoxy]phenyl]aMino]-3-oxo-
物理化学性质
沸点596.3±50.0 °C(Predicted)
密度1.708
储存条件Sealed in dry,Room Temperature
酸度系数(pKa)3.16±0.32(Predicted)
常见问题列表
生物活性
Eprotirome (KB2115) 是肝脏选择性甲状腺激素受体 (thyroid hormone receptor, TR) 激动剂。KB2115 对 TRβ 的亲和力略高于 TRα。Eprotirome 降低了低密度脂蛋白 (LDL) 胆固醇的浓度，可用于血脂异常和肥胖症的研究。靶点
Thyroid hormone receptor
体内研究
Eprotirome is a liver-selective thyroid hormone receptor agonist. Histological analysis of livers from mice treated with Eprotirome reveals that Eprotirome elicits a near complete elimination of lipid filled vacuoles that are characteristic of the livers from untreated control mice. Eprotirome treated mice also exhibit increased fasting glucose, but Eprotirome does not increase fasting insulin levels. Glucose levels of mice treated with Eprotirome continues to increase over time, leading to pronounced hyperglycemia by the end of the study. Temperature of mice treated with Eprotirome is decreased relative to untreated control mice.