356783-10-3
中文名称
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%)
CAS
356783-10-3
分子式
C10H15FN3O15P3·x(Na)
356783-10-3 结构式
基本信息
英文别名
T-705RTP sodiumT-705RTP Sodium Salt (>75%)
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-pyrazinecarboxamide Sodium Salt (>75%)
常见问题列表
生物活性
T-705RTP sodium 是一种具有具有选择性和 GTP 竞争性的流感病毒 RNA 聚合酶 (RNA polymerase) 抑制剂，IC50 为 0.14 μM，Ki 为 1.52 μM。T-705RTP sodium 是 T-705 的活性三磷酸盐代谢产物，具有有效的抗流感病毒活性。体外研究
T-705RTP sodium and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP sodium inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner.
T-705RTP sodium inhibits the incorporation of ATP and GTP in a competitive manner with K
i
values of 7.72 and 1.56 μM, respectively. T-705RTP sodium inhibits the incorporation of CTP in a mixed-type manner with a K
i
value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner.
The incorporation of a single molecule of T-705RTP sodium (10-1000 μM) inhibits influenza virus RNA strand extension.