382180-17-8
中文名称
N-羟基-N'-3-吡啶基辛二酰胺
英文名称
Pyroxamide
CAS
382180-17-8
分子式
C13H19N3O3
分子量
265.31
MOL 文件
382180-17-8.mol
更新日期
2023/03/20 15:41:27
382180-17-8 结构式
基本信息
中文别名
N-羟基-N'-3-吡啶基辛二酰胺 英文别名
PyroxamideNSC 696085
Pyroxamide
PyroxaMide (NSC 696085)
Pyroxamide ISO 9001：2015 REACH
N-Hydroxy-N'-3-pyridinyloctanediamide
N1-Hydroxy-N8-3-pyridinyl-octanediamide
n-hydroxy-n'-(pyridin-3-yl)octanediamide
Octanediamide, N1-hydroxy-N8-3-pyridinyl-
N1-Hydroxy-N8-(pyridin-3-yl)octanediamide
所属类别
医药中间体：羟基吡啶
N-羟基-N'-3-吡啶基辛二酰胺价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-13216 | N-羟基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 5mg | 500元 |
| 2024/04/30 | HY-13216 | N-羟基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 10mM * 1mLin DMSO | 550元 |
| 2024/04/30 | HY-13216 | N-羟基-N'-3-吡啶基辛二酰胺 Pyroxamide | 382180-17-8 | 10mg | 850元 |
常见问题列表
生物活性
Pyroxamide 是一种有效的组蛋白脱乙酰基酶 1 (HDAC1) 抑制剂，ID50 为 100 nM。 Pyroxamide 可以诱导白血病细胞凋亡和细胞周期停滞。靶点
ID50: 100 nM
体外研究
Pyroxamide (1.25-20.0 μM; 24-72 hours) suppresses RD and RH30B cells growth, pyroxamide resulted in 44% dead cells for 72 h at 20.0 μM, results in 86% dead cells in culture. Pyroxamide (10.0-20.0 μM; 48 hours) shows sub-G1 fractions of 45.0% and 72.3% at 10.0 and 20.0 μM, respectively.
Cell Viability Assay
| Cell Line: | RD cells; RH30B cells |
| Concentration: | 1.25-20.0 μM |
| Incubation Time: | 24 hours; 48 hours; 72 hours |
| Result: | Resulted in a cell growth decrease in RD and RH30B cells. |
Cell Cycle Analysis
| Cell Line: | RD cells; RH30B cells |
| Concentration: | 10.0 μM; 20.0 μM |
| Incubation Time: | 48 hours |
| Result: | Increased the sub-G1 fractions at 48 hours compared with control samples. |