40592-88-9
中文名称
TLR4-IN-C34
英文名称
Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
CAS
40592-88-9
分子式
C17H27NO9
分子量
389.398
MOL 文件
40592-88-9.mol
更新日期
2023/06/26 10:40:54
40592-88-9 结构式
基本信息
中文别名
ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY á-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE 英文别名
C34TLR4-C34
TLR4-IN-C34
2-Acetamidopyranoside
Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside
ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE
Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
1-Methylethyl 2-(acetylamino)-2-deoxy-a-Dglucopyranoside 3,4,6-triacetate
1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate
Isopropyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-glucopyranoside, Min. 98%
所属类别
生物化工：抑制剂物理化学性质
沸点519.8±50.0 °C(Predicted)
密度1.21±0.1 g/cm3(Predicted)
储存条件-20°C
溶解度H2O: 可溶1mg/mL, 澄清 (加热)
酸度系数(pKa)13?+-.0.70(Predicted)
形态粉末
颜色白色至米色
水溶解性H2O: 1mg/mL, clear (warmed)
常见问题列表
用途
TLR4-IN-C34是一类新的toll样受体4 (TLR4)抑制剂，是潜在的抗炎药物。生物活性
TLR4-IN-C34 是具有口服活性的 TLR4 抑制剂，可改善内毒素血症和坏死性小肠结肠炎模型的全身炎症。体内研究
TLR4-IN-C34 (C34, 1 mg/kg, orally daily) could attenuate NEC severity and demonstrates a marked preservation of the intestinal mucosa.
| Animal Model: | Experimental NEC induced in 7-8 day old mice. |
| Dosage: | 1 mg/kg. |
| Administration: | Orally every morning. |
| Result: | Attenuated intestinal inflammation. |