414858-02-9
中文名称
普乐沙福杂质F
英文名称
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
CAS
414858-02-9
分子式
C46H84N12
分子量
805.24
MOL 文件
414858-02-9.mol
414858-02-9 结构式
基本信息
中文别名
普乐沙福杂质F盐酸普乐沙福杂质2
英文别名
Plerixafor Impurity FPlerixafor Impurity 21
Plerixafor Impurity 2 HCl
1,8-Bis[[4-(1,4,8,11-tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-Cyclotetradecane
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane
所属类别
分析化学：药典标准品和杂质标准品应用领域
用途一
1,8-Bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1,4,8,11-tetraazacyclotetradecane is an impurity of Plerixafor (P580500), a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with granulocyte-colony stimulating factor (G-CSF) to mobilize HSCs to the peripheral blood for collection and subsequent autologous transplantation in patients with non-Hodgkin''s lymphoma (NHL) and multiple myeloma (MM).