42058-59-3
42058-59-3 结构式
基本信息
3-羟基苯乙酸甲酯
3-羟基苯基乙酸甲酯
2-(3-羟基苯基)乙酸甲酯
Methyl m-hydroxyphenylacetate
METHYL 3-HYDROXYPHENYL ACETATE
Methyl 3-hydroxybenzeneacetate
Methyl 2-(3-hydroxyphenyl)acetate
3-HYDROXYPHENYLACETIC ACID METHYL ESTER
2-(3-Hydroxyphenyl)acetic acid methyl ester
Benzeneacetic acid, 3-hydroxy-, methyl ester
物理化学性质
制备方法
67-56-1
621-37-4
42058-59-3
步骤1: 将3-羟基苯基乙酸(15.2 g, 0.1 mol, 1.0当量)和浓硫酸(392 mg, 4 mmol, 0.04当量)溶解于甲醇(100 mL)中。将反应混合物在室温下搅拌1小时，随后用氢氧化钠溶液淬灭反应。用乙酸乙酯萃取反应混合物，有机层用无水硫酸钠干燥后，减压浓缩。通过硅胶柱色谱法(洗脱剂:石油醚/乙酸乙酯=5:1)纯化粗产物，得到2-(3-羟基苯基)乙酸甲酯，为黄色油状物(14.2 g, 产率86%)。1H NMR (400 MHz, CDCl3) δ= 7.15-7.19 (m, 1H), 6.81 (d, 1H), 6.72-6.76 (m, 2H), 5.88 (s, 1H), 3.70 (s, 3H), 3.58 (s, 2H); LCMS m/z 167 [M + 1]+。
参考文献：
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 21, p. 5488 - 5492
[2] Patent: WO2004/63155, 2004, A1. Location in patent: Page 58
[3] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 51
[4] Patent: WO2005/19190, 2005, A2. Location in patent: Page/Page column 51
[5] Patent: WO2005/103050, 2005, A2. Location in patent: Page/Page column 168