42422-68-4
中文名称
B-赤霉醇
英文名称
BETA-ZEARALANOL
CAS
42422-68-4
分子式
C18H26O5
分子量
322.4
MOL 文件
42422-68-4.mol
更新日期
2025/04/30 08:34:56
42422-68-4 结构式
基本信息
中文别名
B-赤霉醇Β-玉米赤霉醇
-ZEARALANOL
英文别名
P-1560taleranol
β-Zeranol
BETAZERANOL
B-zearalanol
β-Zearalanol
BETA-ZEARALANOL
Zearalanol, beta-
P-1560【pharmaceutical】
Taleranol (β-Zearalanol)
所属类别
分析化学：食品和化妆品标准品物理化学性质
熔点134-137°C
沸点576.0±50.0 °C(Predicted)
密度1.153±0.06 g/cm3(Predicted)
闪点2℃
储存条件2-8°C
溶解度Methanol: 10 mg/ml
酸度系数(pKa)8.08±0.60(Predicted)
形态固体
颜色White to off-white
BRN4844761
B-赤霉醇价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2025/02/08 | HY-N6740 | B-赤霉醇 Beta-Zearalanol | 42422-68-4 | 5mg | 1600元 |
| 2025/02/08 | HY-N6740 | B-赤霉醇 Beta-Zearalanol | 42422-68-4 | 10 mM * 1 mLin DMSO | 1760元 |
| 2025/02/08 | HY-N6740 | B-赤霉醇 Beta-Zearalanol | 42422-68-4 | 10mg | 2600元 |
常见问题列表
生物活性
Beta-Zearalanol 是由镰刀菌属 Fusarium 产生的一种霉菌毒素，可以在哺乳动物生殖细胞中引起细胞凋亡 (apoptosis) 和氧化应激反应。 Beta-Zearalanol 是玉米赤霉烯酮（ZEA）的衍生物，可以与葡萄糖醛酸 (glucuronic acid) 结合。体外研究
βeta-Zearalenol (0-200 μM; 24 hours) inhibits BGC proliferation in a dose-dependent manner, with an IC 50 of 25 μM. βeta-Zearalenol (0-100 μM; 72 hours) shows high toxic with an IC 50 of 15.2 μM in the HepG2 cells, synergistic effect of β-ZOL+ZEN or β-ZOL+α-ZOL with IC 50 values of 19.8 uM, 16.8 uM, respectively. βeta-Zearalenol (0-10 μM; 72 hours) has the highest inhibition effect on the all three investigated cytokines: IL-8, IL-1β and TNF-α by comparation with ZEA or α-Zearalenol.
Cell Viability Assay
| Cell Line: | HepG2 cells |
| Concentration: | 0-100 μM |
| Incubation Time: | 72 hours |
| Result: | Shown a dose-dependent reduction of viability of cells treated with Beta-Zearalanol. |
Cell Proliferation Assay
| Cell Line: | BGC cells |
| Concentration: | 0 μM, 5 μM, 10 μM, 15 μM, 25 μM, 50 μM, 100 μM, and 200 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited cell proliferation in a dose-dependent manner. |
RT-PCR
| Cell Line: | HepG2 cells |
| Concentration: | 1 μM, 5 μM, 10 μM |
| Incubation Time: | 72 hours |
| Result: | Had the higher cytotoxic effect in comparation with α-Zearalenol. |