4366-18-1
4366-18-1 结构式
基本信息
中文别名
库美香豆素库美香豆素,双香豆素醚
英文别名
Ph 137Cumetarol
Cumetharol
coumetarol
Dicumoxane
Dicoumoxyl
Cumethoxethan
3,3'-(2-Methoxyethylidene)bis(4-hydroxycoumarin)
2H-1-Benzopyran-2-one, 3,3'-(2-methoxyethylidene)bis[4-hydroxy-
2-hydroxy-3-[1-(2-hydroxy-4-keto-chromen-3-yl)-2-methoxy-ethyl]chromone
物理化学性质
熔点156-157°
沸点639.9±55.0 °C(Predicted)
密度1.514±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)4.20±1.00(Predicted)
常见问题列表
生物活性
Coumetarol (Dicumoxane) 是维生素 K 拮抗剂。靶点
vitamin K
体外研究
Coumetarol (Dicumoxane), an oral anticoagulant, is active in both models. The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model. Treatment with the vitamin K antagonist Coumetarol in a dose of 25 mg/kg p.o. twice daily for 2 days results in a significant reduction in thrombus weight by 50% in the venous stasis model and by 75% in the arterio-venous shunt model. In both experiments the coagulation time as measured by the Thrombotest is prolonged to the same extent.