47439-36-1

中文名称 Nitroxazepine

英文名称 Nitroxazepine

CAS 47439-36-1

分子式 C18H19N3O4

分子量 341.36

MOL 文件 47439-36-1.mol

47439-36-1 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物NITROXAZEPINE

英文别名

CIBA 2330Go
Dibenz[b,f][1,4]oxazepin-11(10H)-one, 10-[3-(dimethylamino)propyl]-2-nitro-

物理化学性质

熔点84-85 °C(Solv: hexane (110-54-3))

沸点514.3±50.0 °C(Predicted)

密度1.270±0.06 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)9.32±0.28(Predicted)

常见问题列表

生物活性

Nitroxazepine 是一种三环抗抑郁化合物 (TCA)，可用于抗抑郁的研究。Nitroxazepin 作为 5-羟色胺去甲肾上腺素再摄取抑制剂。

靶点

serotonin-norepinephrine reuptake

体外研究

The in vitro effect of Nitroxazepine (Sintamil), as a modulator alone and in combination with hydroxyurea (HU), on cytotoxicity is studied in 16 cases of human chronic myeloid leukemia (CML). The cytotoxicity of the drugs as a function of the exposure dose (HU, 100 μM; Nitroxazepine, 10 μg/mL) and the exposure time (1 h) to the agent is investigated. Cytotoxicity is evaluated as the inhibition of incorporation of [ ³ H-methyl]thymidine in the nucleic acids of CML cells. Cytotoxicity of HU is greatly enhanced (P<0.001) by 1 h exposure of the CML cells to Nitroxazepine. The present data indicate that Nitroxazepine potentiates the cytotoxic activity of HU in CML cells. Nitroxazepine is indicated for the treatment of nocturnal enuresis. Nitroxazepine has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.