490-31-3
中文名称
洋槐黄素
英文名称
ROBINETIN
CAS
490-31-3
分子式
C15H10O7
分子量
302.24
MOL 文件
490-31-3.mol
更新日期
2024/05/06 11:39:30
490-31-3 结构式
基本信息
中文别名
洋槐黄素洋槐黄素对照品
洋槐黄素标准品
英文别名
ROBINETINnorkanugin
5-HYDROXYFISETIN
5-HYDROXYFISETIN hplc
3,3’,4’,5’,7-pentahydroxy-flavon
3,7,3',4',5'-PENTAHYDROXYFLAVONE
3,7,3'',4'',5''-PENTAHYDROXYFLAVONE WITH HPLC
3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4-benzopyrone
3,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chromen-4-one
3,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on
所属类别
天然产物：黄酮类化合物物理化学性质
熔点326-328°C
沸点363.28°C (rough estimate)
密度1.3616 (rough estimate)
折射率1.4790 (estimate)
储存条件Sealed in dry,2-8°C
溶解度DMSO（微溶）、甲醇（微溶，加热）
酸度系数(pKa)6.82±0.40(Predicted)
形态固体
颜色黄色至深黄色
LogP2.550 (est)
常见问题列表
生物活性
Robinetin (3,3',4',5',7-Pentahydroxyflavone) 是一种天然黄酮，具有显着的“两种颜色”固有荧光特性，具有抗真菌、抗病毒、抗菌、抗突变和抗氧化活性。Robinetin 还可以抑制脂质过氧化和蛋白质糖基化。体外研究
Robinetin (0.1-10 μM; 1 h) inhibits HIV integrase cleavage and integration in a dose-dependent manner.
Robinetin inhibits the DNA synthesis in
Proteus vulgaris
, and the RNA synthesis in S.
aureus
.
Robinetin (100-200 or 25 μM; 1 or 72 h) inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency.
Robinetin exhibits photo-induced excited-state intramolecular proton transfer resulting in ‘two color’ (in ‘blue-violet’ and ‘yellow-green’ regions) fluorescence characteristic of flavonols, the relative contributions between the two colors being strongly modulated by the local environment of the fluorophore.