5092-09-1
中文名称
柴胡皂苷元A
英文名称
saikogenin A
CAS
5092-09-1
分子式
C30H48O4
分子量
472.7
MOL 文件
5092-09-1.mol
更新日期
2025/05/06 16:53:49
5092-09-1 结构式
基本信息
中文别名
柴胡皂苷元A 标准品 英文别名
Clinopodiside A1Oleana-11,13(18)-diene-3,16,23,28-tetrol, (3β,4α,16β)-
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点287-293 °C
沸点607.4±55.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)14.47±0.70(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Saikogenin A 可从中药柴胡中提取，是一种二肽基肽酶 IV (DPP-IV) 抑制剂。靶点
DPP-IV
体外研究
Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide.
体内研究
Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation.