51276-47-2
51276-47-2 结构式
基本信息
中文别名
草氨瞵 英文别名
C05042HOE-866
HOE-35956
Phosphinothricin
IAJOBQBIJHVGMQ-UHFFFAOYSA-N
Phosphinothricin ammonium salt
2-amino-4-(hydroxymethylphosphinyl)butyric acid
2-Amino-4-(methylhydroxyphosphinyl)butyric acid
物理化学性质
熔点229-231° (dec)
沸点519.1±45.0 °C(Predicted)
密度1.378±0.06 g/cm3(Predicted)
溶解度Aqueous Acid (Slightly), Methanol (Very Slightly, Sonicated), Water (Slightly)
酸度系数(pKa)2.22±0.10(Predicted)
形态固体
颜色白色至浅米色
稳定性吸湿性
LogP-0.750 (est)
常见问题列表
生物活性
Glufosinate 是谷氨酸的膦酸类似物，是一种由植物细胞转化为 PT (L-phosphinothricin) 的除草剂。Glufosinate 具有神经毒性作用。体外研究
Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs).
Glufosinate (1-100 μM; 12DIV) significantly decreases
Celsr2
gene expression at 100 μM.
Glufosinate impairs ependymal cell capability to synthetize cilia.
体内研究
Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats.
The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats.