585-23-9
中文名称
化合物 ALBIZZIIN
英文名称
3-[(aminocarbonyl)amino]alanine
CAS
585-23-9
分子式
C4H9N3O3
分子量
147.13
MOL 文件
585-23-9.mol
585-23-9 结构式
基本信息
中文别名
化合物 ALBIZZIIN 英文别名
2-Amino-3-ureidopropanoic acid3-[(aminocarbonyl)amino]alanine
(3S)-3-amino-3-ureido-propionic acid
(3S)-3-amino-3-(carbamoylamino)propanoic acid
3-[(Aminocarbonyl)amino]-2-aminopropionic acid
(3S)-3-(aminocarbonylamino)-3-azanyl-propanoic acid
应用领域
用途一
Albizziin is amino acid analog which acts as a competitive inhibitor of asparagine synthetase with respect to glutamine. Albizziin has been used to isolate mutants of Chinese hamster ovary cells with alterations in levels of the target enzyme. Several classes of mutations can be distinguished on the basis of cross-resistance to beta-aspartyl hydroxamate, another amino acid analog. Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification.