5874-97-5

中文名称硫酸奥西那林

英文名称 Orciprenaline sulfate

CAS 5874-97-5

分子式 C22H36N2O10S

分子量 520.59

MOL 文件 5874-97-5.mol

更新日期 2025/03/21 10:44:06

5874-97-5 结构式

基本信息物理化学性质安全数据图谱信息硫酸奥西那林价格(试剂级) 常见问题列表

基本信息

中文别名

硫酸异丙喘宁
硫酸奥西那林
硫酸奥昔帕林
异丙喘宁硫酸盐
奥西那林硫酸盐
硫酸奥肾上腺素
奥西那林半硫酸盐
硫酸奥西那林标准品
硫酸奥西那林(异丙喘宁)
奥西那林半硫酸盐标准品

英文别名

alotec
th-152
alupent
metaprel
Astmopent
novasmasol
ORCIPRENALINE SULFATE
METAPROTERENOL SULFATE
dl-Orciprenaline sulfate
METAPROTERENOLSULFATE,USP

所属类别

原料药：平喘药

物理化学性质

熔点202-203°

储存条件2-8°C

溶解度Freely soluble in water, slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.

形态neat

颜色白色至灰白色

稳定性吸湿性

主要应用pharmaceutical (small molecule)

InChI1S/2C11H17NO3.H2O4S/c2*1-7(2)12-6-11(15)8-3-9(13)5-10(14)4-8;1-5(2,3)4/h2*3-5,7,11-15H,6H2,1-2H3;(H2,1,2,3,4)

InChIKeyMKFFGUZYVNDHIH-UHFFFAOYSA-N

SMILESOS(O)(=O)=O.CC(C)NCC(O)c1cc(O)cc(O)c1.CC(C)NCC(O)c2cc(O)cc(O)c2

安全数据

危险性符号(GHS) GHS hazard pictograms

GHS07

警示词警告

危险性描述H332

防范说明P261-P271-P304+P340+P312

危险品标志Xn

危险类别码20

安全说明36

WGK Germany2

RTECS号DO2275000

海关编码2922504500

存储类别11 - Combustible Solids

危险性类别Acute Tox. 4 Inhalation

毒性LD50 in rats (mg/kg): 42 orally (Goldenthal)

图谱信息

硫酸奥西那林(5874-97-5)核磁图(¹HNMR)

硫酸奥西那林价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2025/12/22	HY-B1276	硫酸奥西那林 Metaproterenol hemisulfate	5874-97-5	5 mg	171元
2025/12/22	HY-B1276	硫酸奥西那林 Metaproterenol hemisulfate	5874-97-5	10mM * 1mLin DMSO	188元
2025/12/22	HY-B1276	硫酸奥西那林 Metaproterenol hemisulfate	5874-97-5	10 mg	233元

常见问题列表

生物活性

Metaproterenol hemisulfate (Orciprenaline hemisulfate) 是一种直接作用的拟交感神经药，是 β2-肾上腺素能受体 (β2AR) 激动剂，其 IC50 为 68 nM。Metaproterenol hemisulfate 还具有抗炎活性。

靶点

IC50: 68 nM (β2-adrenergic receptor)

体外研究

Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment enhances β-arrestin2 and its interaction with IκBα in high glucose-induced THP-1 cells and bone marrow macrophages.
Metaproterenol (10 μM; 74 hours; THP-1 cells and bone marrow macrophages) treatment leads to downregulation of NF-κB in high glucose-induced THP-1 cells and bone marrow macrophages.

Western Blot Analysis

Cell Line:	THP-1 cells and bone marrow macrophages
Concentration:	10 μM
Incubation Time:	74 hours
Result:	Enhanced β-arrestin2 and its interaction with IκBα.

RT-PCR

Cell Line:	THP-1 cells and bone marrow macrophages
Concentration:	10 μM
Incubation Time:	74 hours
Result:	Led to downregulation of NF-κB.

体内研究

Treatment of Zucker diabetic fatty rats with Metaproterenol for 12 weeks attenuates monocyte activation as well as pro-inflammatory and pro-fibrotic responses in the kidneys and heart. Thus, Metaproterenol might has protective effects against diabetic renal and cardiovascular complications.