69207-52-9
中文名称
methyl 2-tetradecylglycidate
英文名称
methyl 2-tetradecylglycidate
CAS
69207-52-9
分子式
C18H34O3
分子量
298.46
MOL 文件
69207-52-9.mol
69207-52-9 结构式
基本信息
中文别名
帕莫酸甲酯 英文别名
MCN-3716NSC359682)
Methyl parmoxirate
Methyl palmoxirate
McN3716 (Methyl palmoxirate
methyl 2-tetradecylglycidate
2-Tetradecyloxiranecarboxylic acid methyl ester
2-Tetradecyloxirane-2-carboxylic acid methyl ester
methyl 2-tetradecylglycidate价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2023/03/20 | HY-U00159 | methyl 2-tetradecylglycidate McN3716 | 69207-52-9 | 1 mg | 5300元 |
常见问题列表
生物活性
McN3716 是一种肉碱棕榈酰转移酶 I (CPT-1) 抑制剂。靶点
Carnitine palmitoyltransferase I (CPT-1)
体内研究
Inhibition of brain mitochondrial β-oxidation by McN3716 (Methyl palmoxirate, MEP) significantly reduces the levels of all measured HETE and epoxytrienoic acids (EET), nonenzymatic auto-oxidative metabolites of ARA, by 23% to 44% and 32% to 50% compared with vehicle-injected rats, respectively, except for 15-HETE which was unaffected. There is a significant 34% reduction in the level of 6-keto-PGF 1α , a byproduct of PGI 2 (prostacyclin) in McN3716-treated rats. Similarly, the brain level of hydroxyeicosapentaenoic acids, nonenzymatic auto-oxidative metabolites of EPA, is reduced by 35% to 76% upon McN3716 treatment relative to vehicle.