71002-09-0

中文名称吡拉唑酸

英文名称 pirazolac

CAS 71002-09-0

分子式 C17H12ClFN2O2

分子量 330.74

MOL 文件 71002-09-0.mol

71002-09-0 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

吡拉唑酸

英文别名

ZK-76604
pirazolac
4-(4-Chlorophenyl)-1-(4-fluorophenyl)-1H-pyrazole-3-acetic acid
1-(4-Fluorophenyl)-4-(4-chlorophenyl)-1H-pyrazole-3-acetic acid
1H-Pyrazole-3-acetic acid, 4-(4-chlorophenyl)-1-(4-fluorophenyl)-

物理化学性质

熔点148-149°; mp 135-136°

沸点520.8±50.0 °C(Predicted)

密度1.36±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)3.94±0.10(Predicted)

常见问题列表

生物活性

Pirazolac 是一种非甾体抗炎药。

体外研究

Pirazolac is a non-steroidal anti-inflammatory drug. Pirazolac concentration-relatedly inhibits the accumulation of prostanoids in incubates of human gastric mucosa, but this inhibition is less than that by indomethacin and other commonly used non-steroidal anti-inflammatory drugs. This difference may explain the claim that Pirazolac is less damaging to the stomach.