71678-03-0
中文名称
3-[(十氢-1Β,2Β,4AΒ-三甲基-5-亚甲基-1-萘基)甲基]-2-羟基-5-甲氧基苯醌
英文名称
ILIMAQUINONE
CAS
71678-03-0
分子式
C22H30O4
分子量
358.47
MOL 文件
71678-03-0.mol
71678-03-0 结构式
基本信息
中文别名
3-[(十氢-1Β,2Β,4AΒ-三甲基-5-亚甲基-1-萘基)甲基]-2-羟基-5-甲氧基苯醌 英文别名
IQILIMAQUINONE
illimaquinone
(-)-Ilimaquinine
(-)-ILIMAQUINONE
5-Epiilimaquinone
Ilimaquinone - CAS 71678-03-0 - Calbiochem
3-[(decahydro-1β,2β,4aβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
3-[(DECAHYDRO-1B,2B,4AB-TRIMETHYL-5-METHYLENE-1-NAPHTHYL)METHYL]-2-HYDROXY-5-METHOXYBENZOQUINONE
2-[[(1R,8aα)-1,2β,4aβ-Trimethyl-5-methylenedecalin-1α-yl]methyl]-3-hydroxy-6-methoxy-1,4-benzoquinone
物理化学性质
熔点108-110℃ (pentane )
比旋光度D23 -23.2° (c = 1.12 in CHCl3)
沸点478.4±45.0 °C(Predicted)
密度1.14±0.1 g/cm3(Predicted)
储存条件−20°C
溶解度DMSO: Soluble; Ethanol: Soluble; Hexane: Soluble; Methanol: Soluble
酸度系数(pKa)2.92±0.50(Predicted)
形态红色固体
颜色Light yellow to brown
常见问题列表
生物活性
Ilimaquinone 是一种海洋海绵状代谢产物，通过 GADD153 介导的信号通路发挥抗肿瘤活性。Ilimaquinone 可以诱导高尔基体的囊泡化。Ilimaquinone 具有抗病毒，抗菌和抗炎活性。体外研究
Ilimaquinone induces a concentration-dependent anti-proliferative effect in several types of cancer cell lines, including prostate cancer PC-3 and LNCaP, non-small cell lung cancer A549 and hepatocellular carcinoma Hep3B cells. Ilimaquinone (0.3-30 μM ; 48 hours) inhibits the proliferation of PC-3 cells, DU145, LNCaP, MG63, A549, Hep3B cells with GI 50 s of 2.6 μM, 5.8, 4.6, 4.9, 4.1, 12.0μM, respectively.
Cell Viability Assay
| Cell Line: | Prostate cancer PC-3 cells |
| Concentration: | 0.3, 1, 3, 10, and 30 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited the proliferation of PC-3 cells in a concentration-dependent manner. |
体内研究
Ilimaquinone exhibits terminal elimination half-lives (T 1/2 =1.2±0.3 h) due to high plasma clearance (2.95±0.53 L/h/kg) following oral administration (10 mg/kg) in male Sprague-Dawley rats.