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7266-47-9

中文名称 ACTH (1-17)
英文名称 ACTH (1-17)
CAS 7266-47-9
分子式 C95H145N29O23S
分子量 2093.41
MOL 文件 7266-47-9.mol
更新日期 2024/04/26 10:50:36
7266-47-9 结构式 7266-47-9 结构式

基本信息

中文别名
促肾上腺皮质激素片段 (1-17),人
ALPHA1-17-促肾上腺皮质激素
ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-17 HUMAN
ACTH (1-17)
HUMAN
英文别名
ACTH (1-17)
SYSMEHFRWGKPVGKKR
ACTH (1-17), HUMAN
ALPHA 1-17-CORTICOTROPIN
alpha1-17-ACTH
ADRENOCORTICOTROPIC HORMONE (1-27)
alpha1-17-Corticotropin
ADRENOCORTICOTROPIC HORMONE (1-17), HUMAN
ADRENOCORTICOTROPIC HORMONE FRAGMENT 1-17
ADRENOCORTICOTROPIC HORMONE HUMAN FRAGMENT 1-17

物理化学性质

密度1.48±0.1 g/cm3(Predicted)
RTECS号GM7907000
储存条件−20°C

安全数据

WGK Germany3
ACTH (1-17)价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2023/03/20HY-P1545ACTH (1-17)
ACTH (1-17)
7266-47-91mg1300元
2023/03/20HY-P1545ACTH (1-17)
ACTH (1-17)
7266-47-95mg4500元
2023/03/20HY-P1545ACTH (1-17)
ACTH (1-17)
7266-47-910mg6500元

常见问题列表

生物活性
ACTH (1-17) 是促肾上腺皮质激素类似物,是一种有效的人黑皮素受体 (human melanocortin 1 (MC1) receptor) 激动剂,Ki 值为0.21 nM。
靶点

Ki: 0.21 nM (human MC1 receptor)

体外研究

ACTH (1-17) is a potent agonist at the hMC1R. ACTH (1-17) shows high affinity for the hMC1R with a K i value of 0.21±0.03 nM which is slightly higher than that of 0.13±0.005 nM for alpha-MSH. ACTH (1-17) induces a slight and not significant increase in growth hormone secretion even when micromolar concentrations of the peptide are employed in rat pituitary cultures.

体内研究

Inhibition of DNA labeling is noted when the ACTH (1-17) is administered at 2 hr after the beginning of the daily dark span when nocturnal animals become active. When administered at this circadian stage, the larger dose in particular is associated with an inhibition of DNA labeling lasting for 24 hr. The inhibitory effect is much shorter when the same dose is injected 4 hr earlier.

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