740790-94-7
中文名称
UUKPXXBDUCDZDA-KAFVXXCXSA-N
英文名称
UUKPXXBDUCDZDA-KAFVXXCXSA-N
CAS
740790-94-7
分子式
C10H15FN3O15P3
分子量
529.157
MOL 文件
740790-94-7.mol
740790-94-7 结构式
常见问题列表
生物活性
T-705RTP 是一种具有具有选择性和 GTP 竞争性的流感病毒 RNA 聚合酶 (RNA polymerase) 抑制剂，IC50 为 0.14 μM，Ki 为 1.52 μM。T-705RTP 是 T-705 的活性三磷酸盐代谢产物，具有有效的抗流感病毒活性。靶点
IC50: 0.14 μM (Influenza virus RNA polymerase)
Ki: 1.52 μM (Influenza virus RNA polymerase)
体外研究
T-705RTP and T-705RMP are detected in MDCK cells treated with T-705. T-705RTP inhibits influenza virus RNA polymerase activity in a dose-dependent and a GTP-competitive manner.
T-705RTP inhibits the incorporation of ATP and GTP in a competitive manner with K
i
values of 7.72 and 1.56 μM, respectively. T-705RTP inhibits the incorporation of CTP in a mixed-type manner with a K
i
value of 11.3 μM, and also inhibits the incorporation of UTP in a noncompetitive manner.
The incorporation of a single molecule of T-705RTP (10-1000 μM) inhibits influenza virus RNA strand extension.