78331-26-7
中文名称
DerMorphin Trifluoroacetate
英文名称
DerMorphin Trifluoroacetate
CAS
78331-26-7
分子式
C40H50N8O10
分子量
802.873
MOL 文件
78331-26-7.mol
78331-26-7 结构式
常见问题列表
生物活性
Dermorphin TFA 是在两栖类皮肤中发现的一种天然七肽 μ-阿片受体 (MOR) 激动剂。Dermorphin 可用于抑制神经痛。靶点
μ-opioid receptor (MOR)
体外研究
Dermorphin, a peptide isolated from the skin of Phyllomedusa frogs and the peptide receptor (NOP) component by the endogenous agonist nociceptin/orphanin FQ (N/OFQ). In displacement binding studies at CHO hMu , Dermorphin and DeNo displac the binding of [ 3 H]-DPN in a concentration dependent and saturable manner. Dermorphin displays an affinity of 7.17, while N/OFQ fails to displace [ 3 H]-DPN at the Delta receptor. Dermorphin and DeNo stimulate the binding of GTPγ[ 35 S] in a concentration dependent and saturable manner at the Mu receptor.