78538-74-6
78538-74-6 结构式
基本信息
Β-CARBOLINE-3-CARBOXYLIC ACID N-METHYLAMIDE
FG 7142
Zk-31906
ZK 39106
β-CCA methylamide
N-METHYL-BETA-CARBOLINE-3-CARBOXAMIDE
B-carboline-3-carboxylic acid N-*methylamide
4-b)indole-3-carboxamide,n-methyl-9h-pyrido(
n-methyl-9h-pyrido(3,4-b)indole-3-carboxamide
N-METHYL-B-CARBOLINE-3-CARBOXAMIDE (FG-7 142)
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-100991 | FG-7142 FG 7142 | 78538-74-6 | 2mg | 500元 |
| 2024/04/30 | HY-100991 | FG-7142 FG 7142 | 78538-74-6 | 5mg | 1000元 |
| 2024/04/30 | HY-100991 | FG-7142 FG 7142 | 78538-74-6 | 10mM * 1mLin DMSO | 1100元 |
常见问题列表
Ki: 91 nM (GABAA receptor)
FG-7142 has affinity for those expressing the α subunit, the K i values are 91 nM; 330 nM; 492 nM and 2.150 μM for α1, α2,α3 and α5 subunits, respectively. FG-7142 has a high efficacy in modulating GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC 50 = 137 nM) as compared to the other α subunits (EC 50 : α2= 507 nM,α3=1.021μM , α5=1.439 μM).
FG-7142 (intraperitoneal injection; 15-30 mg/kg) activates mesolimbocortical dopaminergic projections, leading to increases in dopamine in the prefrontal cortex and the nucleus accumbens in rats. FG-7142 (intraperitoneal injection; 15 mg/kg) increases tyrosine hydroxylase activity and dopamine turnover in the medial prefrontal cortex and ventral tegmentum in vivo, but effects are not detected in mesolimbic or nigrostriatal areas.