80665-72-1
中文名称
附子灵
英文名称
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)-
CAS
80665-72-1
分子式
C24H39NO7
分子量
453.58
MOL 文件
80665-72-1.mol
更新日期
2024/04/25 08:39:30
80665-72-1 结构式
基本信息
中文别名
附子宁附子灵对照品
FUZILINE 附子灵
英文别名
Senbusine C15-Epinagarine
15-Hydroxyneoline
15-α-hydroxyneoline
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- ,
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)-, (1α,6α,14α,15α,16β)-
Aconitane-1,8,14,15-tetrol, 20-ethyl-6,16-dimethoxy-4-(methoxymethyl)- , (1alpha,6alpha,14alpha,15alpha,16beta)-
物理化学性质
外观性状白色晶体，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于生附子、毛茛科植物乌头子根的加工品。
熔点206-207℃
沸点596.9±50.0 °C(Predicted)
密度1.36±0.1 g/cm3 (20 ºC 760 Torr)
溶解度Chloroform: soluble; DMSO: soluble
酸度系数(pKa)12.78±0.70(Predicted)
形态结晶固体
常见问题列表
生物活性
Fuziline 是一种从附子侧根中分离得到的生物碱。体外研究
Fuziline shows activity against pentobarbital sodiuminduced cardiomyocytes damage by obviously recovering beating rhythm and increasing the cell viability.
体内研究
Fuziline exhibits the mean half-life of 5.93 hours, 6.13 hours and 5.12 hours for 14 mg/kg, 2 4 mg/kg and 4 mg/kg, respectively, by oral administration in rat.