83688-84-0
中文名称
TERTATOLOL
英文名称
1-(tert-butylamino)-3-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]propan-2-ol
CAS
83688-84-0
分子式
C16H25NO2S
分子量
295.44
MOL 文件
83688-84-0.mol
83688-84-0 结构式
基本信息
中文别名
化合物 T17041 英文别名
rac TertatololEinecs 280-519-9
Racemic teraterol
RaceMic Tertatolol
Tertatolol [ban:inn]
83688-85-1 (Hydrochloride)
1-(tert-butylamino)-3-[(3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy]propan-2-ol
2-Propanol, 1-((3,4-dihydro-2H-1-benzothiopyran-8-yl)oxy)-3-((1,1-dimethylethyl)amino)-
1-[[(3,4-Dihydro-2H-1-benzothiopyran)-8-yl]oxy]-3-[(1,1-dimethylethyl)amino]-2-propanol
物理化学性质
熔点70-72 °C
沸点465.0±45.0 °C(Predicted)
密度1.112±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)13.84±0.20(Predicted)
常见问题列表
生物活性
Tertatolol 是一种有效的 beta-adrenoceptor 和 5-HT receptor 拮抗剂，具有舒张血管的作用。体外研究
In serum-free media, tertatolol does not significantly alter the incorporation of 3 H-thymidine after 28 h of incubation in human mesangial cell (HMC). In the presence of 1% serum, tertatolol significantly reduces 3 H-thymidine incorporation. Tertatolol also inhibits 3 H incorporation when PDGF and thrombin are used as the stimulus. Tertatolol inhibits the reduction in planar surface area of HMC induced by angiotensin II. The inhibitory effect of tertatolol on HMC proliferation is also potentiated by ritanserin and MDL 72222, 5HT2 and 5HT3 antagonists, respectively.