847612-12-8

中文名称化合物 T26681

英文名称 ATL-802

CAS 847612-12-8

分子式 C24H22F3N7O3

分子量 513.47

MOL 文件 847612-12-8.mol

847612-12-8 结构式

基本信息物理化学性质应用领域常见问题列表

基本信息

中文别名

化合物 T26681

英文别名

ATL802
ATL-802
ATL 802

物理化学性质

沸点738.0±70.0 °C(Predicted)

密度1.481±0.06 g/cm3(Predicted)

酸度系数(pKa)10.62±0.20(Predicted)

应用领域

用途一

ATL802 is an adenosine A2B Receptor antagonist. After IR, ATL802 treatment significantly improved lung function (increased pulmonary compliance and reduced airway resistance and pulmonary artery pressure) and significantly attenuated proinflammatory cytokine production, neutrophil infiltration, vascular permeability, and edema. ATL802 also significantly improved the function of DCD lungs after EVLP (increased compliance and reduced pulmonary artery pressure). After HR, A549 cells exhibited robust production of interleukin (IL)-8, a potent neutrophil chemokine, which was significantly attenuated by ATL802.

常见问题列表

概述

ATL-802 是一种强效的腺苷 A2B receptor 拮抗剂。ATL-802 有望用于糖尿病的研究。